The HTRF GTP Gi Binding Assay measures the level of Gi protein activation and has the advantage of studying the functional response of GPCRs at one of the earliest receptor-mediated events. This application note features pharmacological data in all models tested using reference agonists and antagonists. The panel of receptors represent a wide variety of membranes and differ in:
- biological roles
- basal activity behaviors
- cellular expression backgrounds
- GPCR expression levels
