Dr Steven Charlton - Professor of Molecular Pharmacology and Drug Discovery
Dr Louise Affleck - Business Development Manager Life Sciences
Catherine Wark - Senior Applications Scientist
Optimizing the receptor binding kinetics of new drugs can have significant benefits, ranging from improved duration of action to enhanced efficacy through the insurmountable antagonism of dynamic physiological systems. Most of the current assays are technically difficult to implement and relatively low-throughput. This talk will review these methods and then describe the development of a novel approach using time-resolved FRET in continuous read mode that is capable of simultaneously measuring the kinetics of hundreds of compounds.